class: center, middle, inverse, title-slide # Contexto biológico <svg aria-hidden="true" role="img" viewBox="0 0 512 512" style="height:1em;width:1em;vertical-align:-0.125em;margin-left:auto;margin-right:auto;font-size:inherit;fill:green;overflow:visible;position:relative;"><path d="M483.55,227.55H462c-50.68,0-76.07-61.27-40.23-97.11L437,115.19A28.44,28.44,0,0,0,396.8,75L381.56,90.22c-35.84,35.83-97.11,10.45-97.11-40.23V28.44a28.45,28.45,0,0,0-56.9,0V50c0,50.68-61.27,76.06-97.11,40.23L115.2,75A28.44,28.44,0,0,0,75,115.19l15.25,15.25c35.84,35.84,10.45,97.11-40.23,97.11H28.45a28.45,28.45,0,1,0,0,56.89H50c50.68,0,76.07,61.28,40.23,97.12L75,396.8A28.45,28.45,0,0,0,115.2,437l15.24-15.25c35.84-35.84,97.11-10.45,97.11,40.23v21.54a28.45,28.45,0,0,0,56.9,0V462c0-50.68,61.27-76.07,97.11-40.23L396.8,437A28.45,28.45,0,0,0,437,396.8l-15.25-15.24c-35.84-35.84-10.45-97.12,40.23-97.12h21.54a28.45,28.45,0,1,0,0-56.89ZM224,272a48,48,0,1,1,48-48A48,48,0,0,1,224,272Zm80,56a24,24,0,1,1,24-24A24,24,0,0,1,304,328Z"/></svg> ### Licenciatura en Ciencias Genómicas, UNAM ### First version: 2021-09-11; Last update: 2021-09-14 --- <style type="text/css"> /* From https://github.com/yihui/xaringan/issues/147 */ .scroll-output { height: 80%; overflow-y: scroll; } /* https://stackoverflow.com/questions/50919104/horizontally-scrollable-output-on-xaringan-slides */ pre { max-width: 100%; overflow-x: scroll; } </style> # Mosquitos <img src="imgs/contexto/mosquito_1.jpg" width="500px" style="display: block; margin: auto;" /> --- ### Perspectives on New Vaccines against Arboviruses Using Insect-Specific Viruses as Platforms https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7999276/ "Arthropod-borne viruses (arboviruses) are global pathogens circulating endemically with local explosive outbreaks and constant encroachment into new locations. Few vaccines against arboviruses exist; most for humans are in development or clinical trials. Insect-specific viruses (ISVs) offer a unique platform for expression of arbovirus proteins, through the creation of ISV/arbovirus chimeras. Studies have shown promising results of these vaccines with several advantages over their wild-type counterparts. In this review, we discuss the current status of these potential vaccines using ISVs." --- ### Uncovering the Worldwide Diversity and Evolution of the Virome of the Mosquitoes Aedes aegypti and Aedes albopictus https://www.mdpi.com/2076-2607/9/8/1653/htm <img src="https://www.mdpi.com/microorganisms/microorganisms-09-01653/article_deploy/html/images/microorganisms-09-01653-g001.png" width="800px" style="display: block; margin: auto;" /> --- ### Uncovering the Worldwide Diversity and Evolution of the Virome of the Mosquitoes Aedes aegypti and Aedes albopictus Utilizando información de bases de datos de RNA-Seq, se busca conocer la diversidad mundial y la evolución del viroma de los mosquitos *Aedes aegypti* y *Aedes albopictus* **Aplicación**: Los virus específicos de insectos pueden utilizarse para generar vacunas contra virus que acarrean los mosquitos --- # Pipeline <img src="./imgs/contexto/pipeline.png" width="400px" style="display: block; margin: auto;" /> --- # Pipeline <img src="./imgs/contexto/pipeline2.png" width="800px" style="display: block; margin: auto;" /> ---